Effects of combined 17β-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture | Zendy

Yingli Shi | Zendy; Xuezhen Luo | Zendy; XiaoYong Zhu | Zendy; Keqin Hua | Zendy; Ying Zhu | Zendy; DaJin Li | Zendy

Open Access

Effects of combined 17β-estradiol with TCDD on secretion of chemokine IL-8 and expression of its receptor CXCR1 in endometriotic focus-associated cells in co-culture

Author(s) -

Yingli Shi,

Xuezhen Luo,

XiaoYong Zhu,

Keqin Hua,

Ying Zhu,

DaJin Li

Publication year - 2006

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei414

Subject(s) - stromal cell , chemokine , endocrinology , medicine , secretion , interleukin 8 , estrogen receptor , receptor , chemistry , endometriosis , cell culture , biology , cytokine , cancer , breast cancer , genetics

Chemokines play an important role in the pathogenesis of endometriosis. In the present study, the transcription of 18 chemokine receptors in eutopic endometrium and ectopic tissue with endometriosis was first analysed by RT-PCR. Dioxin, an air pollutant, and estrogen are reported to be associated with endometriosis. The regulatory mechanisms of dioxin and estrogen in the expression of CXCR1/IL-8 in the corresponding cells will help in elucidating roles of the chemokine in the aetiology of endometriosis.

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