Alterations in the phenotype and function of immune cells in ovariectomy-induced osteopenic mice
Author(s) -
Miguel Ángel GarcíaPérez,
Inmaculada Noguera,
Carlos Hermenegildo,
Alicia MartínezRomero,
Juan J. Tarı́n,
Antonio Cano
Publication year - 2006
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dei413
Subject(s) - endocrinology , medicine , bone marrow , ovariectomized rat , rankl , immune system , bone remodeling , osteoblast , osteopenia , stromal cell , t cell , biology , estrogen , immunology , osteoporosis , receptor , bone mineral , activator (genetics) , in vitro , biochemistry
Within the last few years, much evidence has been presented on the involvement of the immune system in certain types of bone loss, such as activated T cells in rheumatoid arthritis and in periodontitis. Estrogen deficiency induces bone loss; however, how this deficiency affects the immune system has not been sufficiently studied.
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