Spermatogonial survival after grafting human testicular tissue to immunodeficient mice | Zendy

Mieke Geens | Zendy; Gert De Block | Zendy; Ellen Goossens | Zendy; Veerle Frederickx | Zendy; André Van Steirteghem | Zendy; Herman Tournaye | Zendy

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Spermatogonial survival after grafting human testicular tissue to immunodeficient mice

Author(s) -

Mieke Geens,

Gert De Block,

Ellen Goossens,

Veerle Frederickx,

André Van Steirteghem,

Herman Tournaye

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei412

Subject(s) - spermatogenesis , biology , transplantation , andrology , testicle , testicular cancer , medicine , endocrinology , cancer , genetics

The xenografting of pre-pubertal human testicular tissue to an immunodeficient mouse is a theoretical strategy for restoring fertility in childhood cancer patients, while circumventing the risk of malignant recurrence. This study aimed at comparing the grafting of pre-pubertal and adult murine testicular tissue, as well as that of human adult testicular tissue, to two immunodeficient recipients, i.e. Swiss Nude mice and SCID-NOD mice.

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