Open AccessHypospadias: a transgenerational effect of diethylstilbestrol?
Author(s) -
Marijn M. Brouwers,
Wouter F.J. Feitz,
L.A.J. Roelofs,
Lambertus A. Kiemeney,
R.P.E. de Gier,
Nel Roeleveld
Publication year - 2005
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dei398
Subject(s) - diethylstilbestrol , hypospadias , transgenerational epigenetics , medicine , gynecology , oncology , biology , pregnancy , estrogen , genetics , offspring , surgery
In 2002, an increased risk of hypospadias was reported for sons of women exposed to diethylstilbestrol (DES) in utero, suggesting transgenerational effects of DES. The aim of this study was to further assess the association between parental DES exposure and hypospadias in a case-referent study.
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