Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment | Zendy

A Zhou-Cun | Zendy; Sizhong Zhang | Zendy; Yuan Yang | Zendy; Yiongxin Ma | Zendy; Lin Li | Zendy; Wei Zhang | Zendy

Open Access

Single nucleotide polymorphisms of the gonadotrophin-regulated testicular helicase (GRTH) gene may be associated with the human spermatogenesis impairment

Author(s) -

A Zhou-Cun,

Sizhong Zhang,

Yuan Yang,

Yiongxin Ma,

Lin Li,

Wei Zhang

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei388

Subject(s) - gene , rna helicase a , biology , genetics , single nucleotide polymorphism , spermatogenesis , nucleotide , helicase , medicine , endocrinology , genotype , rna

Gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific RNA helicase that is essential for completion of spermatogenesis and is involved in pathogenesis of impaired spermatogenesis in mouse. It is therefore reasonable to postulate that human GRTH gene may also play a role in impaired spermatogenesis in humans. To test this hypothesis, we investigated the possible association between the variations of the GRTH gene and human spermatogenesis impairment.

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