Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss | Zendy

Zhigang C. Wang | Zendy; Joseph A. Hill | Zendy; Edmond J. Yunis | Zendy; Ling Xiao | Zendy; Deborah J. Anderson | Zendy

Open Access

Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss

Author(s) -

Zhigang C. Wang,

Joseph A. Hill,

Edmond J. Yunis,

Ling Xiao,

Deborah J. Anderson

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei366

Subject(s) - trophoblast , pregnancy , immunity , immunology , antigen , medicine , biology , immune system , placenta , genetics , fetus

Women with recurrent pregnancy loss (RPL) and T-helper (Th)1-type immunity to trophoblast antigens have an increased frequency of the IL1B-511*1 promoter variant. Since CD46 gene products also regulate maternal immune responses including Th1 immunity, we investigated whether CD46 gene polymorphisms are also associated with RPL in women with and without Th1 immunity to trophoblast, and the possibility of a synergistic effect with the IL1B-511*1 promoter variant.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research