Limited survival of adult human testicular tissue as ectopic xenograft | Zendy

Stefan Schlatt | Zendy; Ali Honaramooz | Zendy; Jens Ehmcke | Zendy; P.J. Goebell | Zendy; H. Rübben | Zendy; Ravindra Dhir | Zendy; Ina Dobrinski | Zendy; Pasquale Patrizio | Zendy

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Limited survival of adult human testicular tissue as ectopic xenograft

Author(s) -

Stefan Schlatt,

Ali Honaramooz,

Jens Ehmcke,

P.J. Goebell,

H. Rübben,

Ravindra Dhir,

Ina Dobrinski,

Pasquale Patrizio

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei352

Subject(s) - spermatogenesis , biology , germinal epithelium , andrology , testicular sperm extraction , sperm , germline , medicine , embryo , microbiology and biotechnology , genetics , gene , intracytoplasmic sperm injection , in vitro fertilisation

Grafting of testicular tissue into immunodeficient mice has become an interesting and promising scientific tool for the generation of gametes and the study of testicular function. This technique might potentially be used to generate sperm from patients whose testes need to be removed or are destroyed due to therapeutic intervention or as a consequence of disease. Here we explore whether adult human testicular tissue from patients with different testicular pathologies survives as xenograft.

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