Combined estrogen receptor α and estrogen receptor β genotypes influence the age of menarche | Zendy

I. Stavrou | Zendy; C. Zois | Zendy; A. Chatzikyriakidou | Zendy; Ioannis Georgiou | Zendy; Agathocles Tsatsoulis | Zendy

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Combined estrogen receptor α and estrogen receptor β genotypes influence the age of menarche

Author(s) -

I. Stavrou,

C. Zois,

A. Chatzikyriakidou,

Ioannis Georgiou,

Agathocles Tsatsoulis

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei326

Subject(s) - menarche , estrogen , estrogen receptor , estrogen receptor alpha , endocrinology , genotype , medicine , estrogen receptor beta , biology , genetics , breast cancer , gene , cancer

Age at menarche has a strong genetic influence. We reported recently an association between the XbaI (351A-->C)and PvuII (397T-->C) polymorphisms of the estrogen receptor (ER)alpha gene with the age of menarche in Greek adolescents. In the present study, we examined whether ERbeta genotypes alone, or in combination with ERalpha genotypes, may also influence onset of menarche.

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