Tumour necrosis factor-α up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-κB | Zendy

W.G. Cao | Zendy; Mélanie MorinBrureau | Zendy; V. Sengers | Zendy; Christine N. Metz | Zendy; Thierry Roger | Zendy; Rodolphe Maheux | Zendy; Ali Akoum | Zendy

Open Access

Tumour necrosis factor-α up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-κB

Author(s) -

W.G. Cao,

Mélanie MorinBrureau,

V. Sengers,

Christine N. Metz,

Thierry Roger,

Rodolphe Maheux,

Ali Akoum

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei315

Subject(s) - macrophage migration inhibitory factor , stromal cell , transcription factor , cancer research , tumor necrosis factor alpha , microbiology and biotechnology , biology , nf κb , endocrinology , immunology , signal transduction , genetics , cytokine , gene

A series of controlled changes including proliferation, secretion and menstrual shedding occur in the human endometrium during every normal menstrual cycle. Macrophage migration inhibitory factor (MIF), a multifunctional cytokine with numerous proinflammatory, immunomodulatory and angiogenic properties, appears to be expressed in the human endometrium and to follow a regulated cycle phase-dependent expression, but the mechanisms underlying endometrial MIF expression remain to be fully elucidated.

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