Decreased mRNA transcripts of M-phase promoting factor and its regulators in the testes of infertile men | Zendy

Yung Ming Lin | Zendy; YenNi Teng | Zendy; Chia Ling Chung | Zendy; Wan Ching Tsai | Zendy; YingHung Lin | Zendy; Johnny Shinn Nan Lin | Zendy; Pao Lin Kuo | Zendy

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Decreased mRNA transcripts of M-phase promoting factor and its regulators in the testes of infertile men

Author(s) -

Yung Ming Lin,

YenNi Teng,

Chia Ling Chung,

Wan Ching Tsai,

YingHung Lin,

Johnny Shinn Nan Lin,

Pao Lin Kuo

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei285

Subject(s) - messenger rna , andrology , biology , medicine , microbiology and biotechnology , endocrinology , genetics , gene

M-phase promoting factor (MPF), which is comprised of Cyclin B and a catalytic subunit, Cdc2, is a key enzyme required for cells to enter M phase in both mitosis and meiosis. MPF activity is controlled by the stimulatory dephosphorylation of the Cdc25 family and the inhibitory phosphorylation of Wee1. We determined the levels of mRNA transcripts of MPF and its regulators in the testes of infertile men, and evaluated the relationship between the transcript levels and patients' testicular phenotypes and sperm retrieval results.

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