Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? | Zendy

Polat Dursun | Zendy; Ezgi Demirtaş | Zendy; Ahmet Bayrak | Zendy; Hakan Yaralı́ | Zendy

Open Access

Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS?

Author(s) -

Polat Dursun,

Ezgi Demirtaş,

Ahmet Bayrak,

Hakan Yaralı́

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei284

Subject(s) - pon1 , medicine , paraoxonase , endocrinology , polycystic ovary , malondialdehyde , insulin resistance , body mass index , risk factor , lipoprotein , lipid profile , dyslipidemia , diabetes mellitus , cholesterol , insulin , oxidative stress , biology , biochemistry , gene , genotype

Patients with polycystic ovary syndrome (PCOS) may have an increased risk for the development of hypertension and atherosclerotic heart disease (AHD), the pathophysiological mechanisms of which are not clear. Paraoxonase1 (PON1) is a high-density lipoprotein-associated enzyme that prevents oxidative modification of low-density lipoprotein. The aim of this study was to measure the serum levels of PON1 activity in patients with PCOS and to compare with those of regularly cycling controls.

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