Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval | Zendy

Rossella E. Nappi | Zendy; Grazia Sances | Zendy; Benedetta Brundu | Zendy; Stefano Taddei | Zendy; Arianna Sommacal | Zendy; Natascia Ghiotto | Zendy; Franco Polatti | Zendy; Giuseppe Nappi | Zendy

Open Access

Estradiol supplementation modulates neuroendocrine response to M-chlorophenylpiperazine in menstrual status migrainosus triggered by oral contraception-free interval

Author(s) -

Rossella E. Nappi,

Grazia Sances,

Benedetta Brundu,

Stefano Taddei,

Arianna Sommacal,

Natascia Ghiotto,

Franco Polatti,

Giuseppe Nappi

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei260

Subject(s) - medicine , endocrinology , oral contraception , gynecology , family planning , population , research methodology , environmental health

Migraine triggered by oral contraception (OC)-free interval is very common and may be extremely severe, long-lasting and poorly responsive to analgesics (status migrainosus). The serotoninergic (5-HT) system is crucially involved in pain threshold and it is sensitive to estradiol (E2). Therefore, we aimed to assess neuroendocrine correlates of OC status migrainosus in response to the direct central 5-HT agonist meta-chlorophenylpiperazine (m-CPP) and to test the effect of transdermal E2 supplementation of the OC-free interval.

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