Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells | Zendy

Yasushi Hirota | Zendy; Yutaka Osuga | Zendy; Tetsuya Hirata | Zendy; Miyuki Harada | Zendy; Chieko Morimoto | Zendy; Osamu Yoshino | Zendy; Kaori Koga | Zendy; Tetsu Yano | Zendy; Osamu Tsutsumi | Zendy; Yuji Taketani | Zendy

Open Access

Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells

Author(s) -

Yasushi Hirota,

Yutaka Osuga,

Tetsuya Hirata,

Miyuki Harada,

Chieko Morimoto,

Osamu Yoshino,

Kaori Koga,

Tetsu Yano,

Osamu Tsutsumi,

Yuji Taketani

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei255

Subject(s) - mapk/erk pathway , stromal cell , biology , cell growth , inflammation , kinase , protease activated receptor 2 , receptor , protein kinase a , microbiology and biotechnology , endocrinology , medicine , cancer research , immunology , biochemistry , enzyme linked receptor

Inflammation has been proposed to play essential roles in the pathophysiology of endometriosis, in which neutrophils and mast cells have been suggested to be involved. We studied whether the protease-activated receptor 2 (PAR2), which is activated by enzymes from neutrophils and mast cells, in endometriotic stromal cells (ESC) has any implication in the development of the disease.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research