Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues | Zendy

W.S. Chong | Zendy; P.C. Kwan | Zendy; Long Yi Chan | Zendy; PM Chiu | Zendy; Ting Kin Cheung | Zendy; Tze Kin Lau | Zendy

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Expression of divalent metal transporter 1 (DMT1) isoforms in first trimester human placenta and embryonic tissues

Author(s) -

W.S. Chong,

P.C. Kwan,

Long Yi Chan,

PM Chiu,

Ting Kin Cheung,

Tze Kin Lau

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei246

Subject(s) - dmt1 , gene isoform , biology , placenta , embryogenesis , microbiology and biotechnology , transporter , chemistry , biochemistry , embryo , fetus , gene , genetics , pregnancy

Divalent metal transporter 1 (DMT1) is a transmembrane glycoprotein which mediates the proton-coupled transport of a variety of divalent metal ions. Two isoforms, which differ by the presence (DMT1-IRE) or absence (DMT1-nonIRE) of an iron-responsive element (IRE) in their 3' untranslated region, are implicated in apical iron transport and endosomal iron transport respectively. Although the expression pattern of DMT1 isoforms is tissue specific in adult, data regarding its expression in embryonic tissues are lacking.

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