Phosphatidylserine externalization in human sperm induced by calcium ionophore A23187: relationship with apoptosis, membrane scrambling and the acrosome reaction | Zendy

Guillaume Martin | Zendy; Odile Sabido | Zendy; Philippe Durand | Zendy; Rachel Lévy | Zendy

Open Access

Phosphatidylserine externalization in human sperm induced by calcium ionophore A23187: relationship with apoptosis, membrane scrambling and the acrosome reaction

Author(s) -

Guillaume Martin,

Odile Sabido,

Philippe Durand,

Rachel Lévy

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei245

Subject(s) - phosphatidylserine , sperm , propidium iodide , annexin , apoptosis , dna fragmentation , biology , microbiology and biotechnology , acrosome reaction , ionophore , annexin a5 , rhodamine 123 , programmed cell death , biochemistry , membrane , phospholipid , botany , multiple drug resistance , antibiotics

Translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the plasma membrane is a modification of the lipid architecture occurring in sperm. This is one of the earliest signs of apoptosis that can be monitored by the calcium-dependent binding of annexin V.

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