Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition | Zendy

Ahmed Ziyyat | Zendy; Nathalie NaudBarriant | Zendy; Virginie BarraudLange | Zendy; Fabien Le Chevalier | Zendy; O. Kulski | Zendy; T. Lemkecher | Zendy; Morgane Bomsel | Zendy; JeanPhilippe Wolf | Zendy

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Cyclic FEE peptide increases human gamete fusion and potentiates its RGD-induced inhibition

Author(s) -

Ahmed Ziyyat,

Nathalie NaudBarriant,

Virginie BarraudLange,

Fabien Le Chevalier,

O. Kulski,

T. Lemkecher,

Morgane Bomsel,

JeanPhilippe Wolf

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei241

Subject(s) - gamete , oocyte , integrin , zona pellucida , microbiology and biotechnology , spermatozoon , disintegrin , biology , human fertilization , receptor , tetraspanin , peptide , sperm , biochemistry , anatomy , genetics , embryo , cell , metalloproteinase , matrix metalloproteinase

Alpha6beta1 integrin has been proposed to act as a sperm receptor on the mouse oocyte by interacting with spermatozoon fertilin beta. We investigated, in humans, whether oocyte integrins could act similarly in gamete fusion, using a cyclic peptide containing the putative disintegrin-binding domain of human fertilin beta [cyclic FEE (cFEE)] and RGD peptide.

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