Strontium promotes calcium oscillations in mouse meiotic oocytes and early embryos through InsP3 receptors, and requires activation of phospholipase and the synergistic action of InsP3 | Zendy

Di Zhang | Zendy; Lei Pan | Zendy; Linghai Yang | Zendy; Xiaoke He | Zendy; Xiu-Ying Huang | Zendy; Fang-Zhen Sun | Zendy

Open Access

Strontium promotes calcium oscillations in mouse meiotic oocytes and early embryos through InsP3 receptors, and requires activation of phospholipase and the synergistic action of InsP3

Author(s) -

Di Zhang,

Lei Pan,

Linghai Yang,

Xiaoke He,

Xiu-Ying Huang,

Fang-Zhen Sun

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei215

Subject(s) - phospholipase c , microinjection , receptor , calcium , microbiology and biotechnology , oocyte activation , inositol , biology , stimulation , oocyte , inositol trisphosphate , mechanism of action , embryo , biophysics , chemistry , endocrinology , medicine , biochemistry , in vitro

Sr2+ is the most efficient agent for mouse oocyte activation and functions by inducing Ca2+ oscillations. However, its specific mechanism of action remains unknown. Here we investigated the specificity and possible mechanism of Sr2+-induced Ca2+ oscillations in mouse oocytes and early embryos.

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