Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window | Zendy

Emre Seli | Zendy; Umit A. Kayisli | Zendy; Hakan Çakmak | Zendy; Orhan Bükülmez | Zendy; İbrahim Bildirici | Zendy; Ozlem GuzelogluKayisli | Zendy; Aydın Arıcı | Zendy

Open Access

Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window

Author(s) -

Emre Seli,

Umit A. Kayisli,

Hakan Çakmak,

Orhan Bükülmez,

İbrahim Bildirici,

Ozlem GuzelogluKayisli,

Aydın Arıcı

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei188

Subject(s) - leukemia inhibitory factor , salpingectomy , andrology , gynecology , endometrium , endometrial biopsy , medicine , pregnancy , biology , cytokine , interleukin 6 , ectopic pregnancy , genetics

The presence of hydrosalpinges is associated with lower implantation and pregnancy rates in women undergoing IVF-embryo transfer, while salpingectomy improves these parameters. Although the mechanism by which hydrosalpinges affects fertility is not entirely understood, an adverse effect on endometrial receptivity has been postulated. In this study, we hypothesized that the adverse effects of hydrosalpinges on fertility may be in part mediated by inappropriate endometrial expression of leukaemia inhibitory factor (LIF), a cytokine implicated in implantation.

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