Further evidence on the role of heparan sulfate as protamine acceptor during the decondensation of human spermatozoa | Zendy

Marina Romanato | Zendy; Eleonora Regueira | Zendy; MÓNICA S. CAMEO | Zendy; Consuelo Baldini | Zendy; Lucrecia Calvo | Zendy; Juan Carlos Calvo | Zendy

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Further evidence on the role of heparan sulfate as protamine acceptor during the decondensation of human spermatozoa

Author(s) -

Marina Romanato,

Eleonora Regueira,

MÓNICA S. CAMEO,

Consuelo Baldini,

Lucrecia Calvo,

Juan Carlos Calvo

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei124

Subject(s) - protamine sulfate , heparan sulfate , protamine , chemistry , heparin , microbiology and biotechnology , andrology , biochemistry , medicine , biology

Human spermatozoa decondense in vitro upon exposure to heparin and glutathione. Glutathione is also the disulfide bond reducer in vivo, and heparan sulfate, a functional analogue of heparin, has been proposed as the protamine acceptor. The aim of this study was to evaluate the decondensing ability of chemically modified heparins and different glycosaminoglycans (GAGs) on isolated sperm nuclei in vitro, and to analyse the possible role of different GAGs as protamine acceptors.

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