Exogenous granulocyte–macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo
Author(s) -
Hongbo Wang,
Yan Wen,
Mary Lake Polan,
R. Boostanfar,
Michael Feinman,
Barry Behr
Publication year - 2005
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/dei123
Subject(s) - granulocyte macrophage colony stimulating factor , theca , medicine , endocrinology , paracrine signalling , follicular phase , autocrine signalling , biology , follicular fluid , in vivo , andrology , ovarian follicle , cytokine , receptor , microbiology and biotechnology , oocyte , embryo
Expression and selective cellular localization of granulocyte-macrophage colony-stimulating factor (GM-CSF) and its receptor in ovarian tissue imply an autocrine/paracrine role in ovarian function. Evidence indicating a functional role for GM-CSF in ovarian follicular cell function has been provided by studies with GM-CSF knockout (GM-/-) mice, which suggest that GM-CSF influences events associated with murine follicular maturation.
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