Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF | Zendy

Göğşen Önalan | Zendy; Belgin Selam | Zendy; Yusuf Baran | Zendy; Mehmet Cıncık | Zendy; Reşide Önalan | Zendy; Ufuk Gündüz | Zendy; Ali Uğur Ural | Zendy; Recai Pabuçcu | Zendy

Open Access

Serum and follicular fluid levels of soluble Fas, soluble Fas ligand and apoptosis of luteinized granulosa cells in PCOS patients undergoing IVF

Author(s) -

Göğşen Önalan,

Belgin Selam,

Yusuf Baran,

Mehmet Cıncık,

Reşide Önalan,

Ufuk Gündüz,

Ali Uğur Ural,

Recai Pabuçcu

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei068

Subject(s) - follicular fluid , metformin , dna fragmentation , granulosa cell , medicine , endocrinology , follicular phase , apoptosis , infertility , andrology , insulin , biology , pregnancy , programmed cell death , oocyte , embryo , biochemistry , genetics , microbiology and biotechnology

There are limited data about the levels of soluble apoptotic factors and their modulation with therapeutic regimens in IVF cycles. The aim of the current study was to determine follicular fluid, and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in PCOS patients undergoing IVF/ICSI cycles; also to investigate the effects of metformin on these factors and on apoptosis of luteinized granulosa cells.

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