Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele | Zendy

Koji Shiraishi | Zendy; Katsusuke Naito | Zendy

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Increased expression of Leydig cell haem oxygenase-1 preserves spermatogenesis in varicocele

Author(s) -

Koji Shiraishi,

Katsusuke Naito

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei063

Subject(s) - varicocele , oxidative stress , spermatogenesis , andrology , immunohistochemistry , biology , medicine , endocrinology , sperm , leydig cell , male infertility , infertility , luteinizing hormone , genetics , pregnancy , hormone

Oxidative stress is involved in the pathogenesis of testicular disorders. Haem oxygenase-1 (HO-1) plays an important cytoprotective role against oxidative stress. We investigated the presence of oxidative stress, represented by generation of 4-hydroxy-2-nonenal (4-HNE)-modified proteins, and expression of HO-1 in varicocele testes of human.

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