Patients with abnormal sperm parameters have an increased sex chromosome aneuploidy rate in peripheral leukocytes | Zendy

Adele De Palma | Zendy; Nunziatina Burrello | Zendy; Nunziata Barone | Zendy; Rosario D’Agata | Zendy; Enzo Vicari | Zendy; Aldo E. Calogero | Zendy

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Patients with abnormal sperm parameters have an increased sex chromosome aneuploidy rate in peripheral leukocytes

Author(s) -

Adele De Palma,

Nunziatina Burrello,

Nunziata Barone,

Rosario D’Agata,

Enzo Vicari,

Aldo E. Calogero

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei036

Subject(s) - aneuploidy , azoospermia , andrology , biology , karyotype , klinefelter syndrome , chromosome , azoospermia factor , sperm , chromosome abnormality , y chromosome , genetics , infertility , medicine , endocrinology , pregnancy , gene

Patients with oligoasthenoteratozoospermia (OAT) and normal karyotypes have an increased sperm aneuploidy rate. This may be due to an altered intratesticular environment that affects the chromosomal segregation mechanism(s). Alternatively, it may be due to a generalized meiotic and mitotic abnormality. In this case, patients with abnormal spermatogenesis should also have an increased somatic cell aneuploidy rate. To test this hypothesis, we evaluated peripheral leukocyte aneuploidy rate in patients with spermatogenic impairment.

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