Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women | Zendy

Lourdes Ibáñez | Zendy; Adriana Jaramillo | Zendy; Angela Ferrer | Zendy; Francis de Zegher | Zendy

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Absence of hepatotoxicity after long-term, low-dose flutamide in hyperandrogenic girls and young women

Author(s) -

Lourdes Ibáñez,

Adriana Jaramillo,

Angela Ferrer,

Francis de Zegher

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/dei004

Subject(s) - flutamide , antiandrogen , polycystic ovary , medicine , toxicity , testosterone (patch) , hyperandrogenism , endocrinology , urology , androgen , hormone , androgen receptor , prostate cancer , obesity , cancer , insulin resistance

Flutamide is a pure non-steroidal anti-androgen that may be hepatotoxic, when given in high-dose (750 mg/d). Low- to ultralow-doses (250-62.5 mg/day) have been recently explored in patients with Polycystic Ovary Syndrome (PCOS), and these lower doses were found to confer benefit on multiple PCOS markers. There is a need for evidence on the potential hepatotoxicity of low- and ultralow-dose flutamide therapy.

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