Transfer of germinal vesicle to ooplasm of young mice could not rescue ageing-associated chromosome misalignment in meiosis of oocytes from aged mice | Zendy

Longbo Cui | Zendy; Xiu-Ying Huang | Zendy; Fang-Zhen Sun | Zendy

Open Access

Transfer of germinal vesicle to ooplasm of young mice could not rescue ageing-associated chromosome misalignment in meiosis of oocytes from aged mice

Author(s) -

Longbo Cui,

Xiu-Ying Huang,

Fang-Zhen Sun

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh826

Subject(s) - germinal vesicle , andrology , ageing , biology , cytoplast , meiosis ii , meiosis , chromosome , oocyte , sperm , embryo , genetics , medicine , gene

[corrected] Transferring a germinal vesicle (GV) from an aged woman's oocyte into ooplasm from a younger woman has been proposed as a possible way to overcome the problem of age-related decline in female fertility. Here we assessed this possibility by determining whether ooplasts derived from young mice could rescue ageing-associated chromosome misalignment in meiosis of oocytes from aged mice.

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