Natural killer cells and reproductive failure—theory, practice and prejudice | Zendy

Raj Rai | Zendy; Gavin Sacks | Zendy; Geoffrey Trew | Zendy

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Natural killer cells and reproductive failure—theory, practice and prejudice

Author(s) -

Raj Rai,

Gavin Sacks,

Geoffrey Trew

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh804

Subject(s) - miscarriage , infertility , publicity , reproductive immunology , recurrent miscarriage , immunology , peripheral blood , reproductive medicine , reproductive health , natural killer cell , medicine , pregnancy , biology , reproductive technology , population , political science , genetics , environmental health , lactation , biochemistry , cytotoxicity , in vitro , law

The relationship between peripheral blood natural killer (NK) cells and reproductive failure is one of the most controversial areas in reproductive medicine. Amidst much publicity, peripheral blood NK cell testing is being promoted as a useful diagnostic test to guide the initiation of a variety of immunosuppressive therapies amongst patients with either recurrent miscarriage or infertility. We contend (i) that at present there is no scientific basis for the introduction of NK cell testing into routine clinical practice, and (ii) that the use of immunosuppressant agents based on the results of such testing may potentially be harmful.

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