Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males | Zendy

Vincent W. Aoki | Zendy; Lihua Liu | Zendy; Douglas T. Carrell | Zendy

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Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males

Author(s) -

Vincent W. Aoki,

Lihua Liu,

Douglas T. Carrell

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh798

Subject(s) - protamine , sperm , infertility , male infertility , andrology , unexplained infertility , fertility , semen , population , biology , semen analysis , medicine , gynecology , pregnancy , genetics , heparin , environmental health

A significant relationship exists between an abnormally high sperm protamine-1 (P1)/protamine-2 (P2) ratio and male infertility. In this study we investigate whether a decreased P1/P2 ratio is also linked to male infertility and we attempt to describe, at the protein expression level, the underlying cause of sperm P1/P2 deregulation.

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