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We have previously reported the retrospective observation that when at least one embryo, transferred on day 3, expressed sHLA-G above the geometric mean (sHLA-G+) 46 h post-ICSI, there was a marked improvement in both pregnancy (PR) and implantation (IR) rates.

Influence of early ICSI-derived embryo sHLA-G expression on pregnancy and implantation rates: a prospective study