The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome | Zendy

Devrim Ertunç | Zendy; Ekrem C. Tok | Zendy; Ayça Aktaş Şüküroğlu | Zendy; Mehmet Emin Erdal | Zendy; S. Dilek | Zendy

Open Access

The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome

Author(s) -

Devrim Ertunç,

Ekrem C. Tok,

Ayça Aktaş Şüküroğlu,

Mehmet Emin Erdal,

S. Dilek

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh747

Subject(s) - polycystic ovary , metformin , endocrinology , medicine , insulin resistance , insulin , free androgen index , testosterone (patch) , genotype , androgen , biology , hormone , gene , genetics

Recent evidence suggests that one of the modes of action of metformin may be through phosphorylation of the insulin receptor and insulin receptor substrates. With this in mind, we supposed that the G972A variant of insulin receptor substrate-1 (IRS-1) may modulate the response to metformin treatment in women with polycystic ovary syndrome (PCOS).

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