Messenger RNA transcripts of the meiotic regulator BOULE in the testis of azoospermic men and their application in predicting the success of sperm retrieval | Zendy

Yung Ming Lin | Zendy; Pao Lin Kuo | Zendy; YingHung Lin | Zendy; YenNi Teng | Zendy; Johnny Shinn Nan Lin | Zendy

Open Access

Messenger RNA transcripts of the meiotic regulator BOULE in the testis of azoospermic men and their application in predicting the success of sperm retrieval

Author(s) -

Yung Ming Lin,

Pao Lin Kuo,

YingHung Lin,

YenNi Teng,

Johnny Shinn Nan Lin

Publication year - 2005

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh647

Subject(s) - biology , meiosis , sperm , spermatogenesis , azoospermia , sperm retrieval , andrology , testicular sperm extraction , medicine , gene , infertility , endocrinology , genetics , pregnancy

Testicular sperm retrieval can lead to paternity for azoospermic patients with spermatogenic failure. The human BOULE gene, a meiotic regulator of germ cells, is a gene whose altered expression may be associated with sterility. We determined the levels of BOULE transcripts in the testes of azoospermic patients, and evaluated the relationship between BOULE transcript levels and patients' testicular phenotypes, clinical parameters and sperm retrieval results.

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