Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis | Zendy

Frédérique M. van Dunné | Zendy; Carine J.M. Doggen | Zendy; Martin B.A. Heemskerk | Zendy; Frits R. Rosendaal | Zendy; Frans M. Helmerhorst | Zendy

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Factor V Leiden mutation in relation to fecundity and miscarriage in women with venous thrombosis

Author(s) -

Frédérique M. van Dunné,

Carine J.M. Doggen,

Martin B.A. Heemskerk,

Frits R. Rosendaal,

Frans M. Helmerhorst

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh640

Subject(s) - miscarriage , factor v leiden , fecundity , venous thrombosis , medicine , obstetrics , thrombosis , factor v , pregnancy , gynecology , genetics , biology , population , environmental health

Factor V Leiden mutation (Arg506Gln) increases the likelihood of venous thrombosis; it may also have a positive effect through facilitation of embryo implantation. This may manifest itself as a reduced time to pregnancy (increased fecundity) and fewer miscarriages in the first trimester.

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