Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway | Zendy

Stephan Weidinger | Zendy; Artur Mayerhofer | Zendy; Lars Kunz | Zendy; M. Albrecht | Zendy; M. Sbornik | Zendy; E. Wunn | Zendy; R. Hollweck | Zendy; Johannes Ring | Zendy; F.M. Köhn | Zendy

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Tryptase inhibits motility of human spermatozoa mainly by activation of the mitogen-activated protein kinase pathway

Author(s) -

Stephan Weidinger,

Artur Mayerhofer,

Lars Kunz,

M. Albrecht,

M. Sbornik,

E. Wunn,

R. Hollweck,

Johannes Ring,

F.M. Köhn

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh618

Subject(s) - motility , protein kinase a , microbiology and biotechnology , mitogen activated protein kinase , tryptase , kinase , chemistry , andrology , biology , medicine , immunology , mast cell

We previously localized protease-activated receptor 2 (PAR-2) on human spermatozoa and demonstrated that activation of PAR-2 by the mast cell (MC) product tryptase inhibits sperm motility. Importantly, tryptase-secreting MCs are encountered in the male and female genital tract, implying that MC-spermatozoa interactions may be as yet unrecognized factors affecting sperm fertilizing ability. In order to elucidate how tryptase via activation of PAR-2 acts in human spermatozoa, we studied intracellular signal transduction events.

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