No association of estrogen receptor α and cytochrome P450c17α polymorphisms with age at menopause in a Dutch cohort | Zendy

Helen S. Kok | Zendy; N. Charlotte OnlandMoret | Zendy; Kristel M. van Asselt | Zendy; Carla H. van Gils | Zendy; Yvonne T. van der Schouw | Zendy; Diederick E. Grobbee | Zendy; Petra H. Peeters | Zendy

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No association of estrogen receptor α and cytochrome P450c17α polymorphisms with age at menopause in a Dutch cohort

Author(s) -

Helen S. Kok,

N. Charlotte OnlandMoret,

Kristel M. van Asselt,

Carla H. van Gils,

Yvonne T. van der Schouw,

Diederick E. Grobbee,

Petra H. Peeters

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh600

Subject(s) - menopause , genotype , biology , allele , polymorphism (computer science) , medicine , cohort , estrogen receptor alpha , genetics , estrogen , estrogen receptor , gene polymorphism , endocrinology , gene , breast cancer , cancer

Age at menopause is under strong genetic control. So far, genetic variations of only one gene, the PvuII polymorphism of the estrogen receptor alpha (ERalpha) gene, have been shown to be associated with age at onset of menopause. This study aims to investigate whether PvuII, XbaI and B-variant polymorphisms of the ERalpha gene, and the MspAI polymorphism of the cytochrome P450c17alpha (CYP17) gene are associated with age at menopause in a Dutch cohort.

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