High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates | Zendy

Maite de Llanos | Zendy; José Luís Ballescà | Zendy; Cristina Gázquez | Zendy; Ester Margarit | Zendy; Rafael Oliva | Zendy

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High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates

Author(s) -

Maite de Llanos,

José Luís Ballescà,

Cristina Gázquez,

Ester Margarit,

Rafael Oliva

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh582

Subject(s) - y chromosome microdeletion , andrology , gynecology , infertility , karyotype , semen , population , oligospermia , y chromosome , male infertility , biology , medicine , chromosome , genetics , pregnancy , gene , environmental health

The Y chromosome gr/gr microdeletion eliminates two copies of the DAZ gene and several additional transcriptional units and has been associated as a risk factor for infertility. Our objective was to study the presence of the gr/gr deletion in ICSI candidates in our population and to determine whether the laboratory, clinical and ICSI outcome were different in the gr/gr deleted patients.

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