Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss | Zendy

Susan A. AdeoyaOsiguwa | Zendy; Lynn R. Fraser | Zendy

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Cathine and norephedrine, both phenylpropanolamines, accelerate capacitation and then inhibit spontaneous acrosome loss

Author(s) -

Susan A. AdeoyaOsiguwa,

Lynn R. Fraser

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh566

Subject(s) - capacitation , acrosome reaction , adenylyl cyclase , pertussis toxin , sperm , chemistry , stimulation , receptor , acrosome , boar , endocrinology , medicine , andrology , in vitro , g protein , biochemistry , biology

Cathinone, released when Catha edulis leaves (khat) are chewed, has euphoric, stimulatory properties. It is metabolized to the phenylpropanolamines (PPAs) cathine and norephedrine. This study investigated whether PPAs affect mammalian sperm function, using primarily mouse, but also human, spermatozoa.

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