Significance of ovarian histology in the management of patients presenting a premature ovarian failure
Author(s) -
Nathalie Massin,
A. Gougeon,
Geri Méduri,
E Thibaud,
Kathleen Laborde,
C Matuchansky,
Elisabeth Constancis,
M.-C. Vacher-Lavenu,
BernardJean Paniel,
J.R. Zorn,
Micheline Misrahi,
F Kuttenn,
P. Touraine
Publication year - 2004
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deh461
Subject(s) - premature ovarian failure , histology , medicine , gynecology
Premature ovarian failure (POF) is a heterogeneous syndrome, possibly due to mutations of genes involved in the normal development of the ovary and/or follicles. Based essentially on animal models, these mutations are associated with various ovarian phenotypes, from a complete absence of follicles to a partial follicular maturation. The aim of the present study was to determine whether ovarian histology, compared to pelvic ultrasonography, would be helpful in identifying which patients display an impaired follicular reserve and/or growth, and in orientating the search for POF aetiology.
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