Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1β and hCG in human endometrial cells | Zendy

Jihong Kang | Zendy; Ali Akoum | Zendy; Pierre Chapdelaine | Zendy; Philippe Y. Laberge | Zendy; Patrice E. Poubelle | Zendy; Michel A. Fortier | Zendy

Open Access

Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1β and hCG in human endometrial cells

Author(s) -

Jihong Kang,

Ali Akoum,

Pierre Chapdelaine,

Philippe Y. Laberge,

Patrice E. Poubelle,

Michel A. Fortier

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh458

Subject(s) - monocyte , chemotaxis , endometrium , endocrinology , medicine , biology , andrology , immunology , receptor

Inflammatory mediators such as prostaglandins (PG), chemokines, cytokines and their interactions regulate reproductive functions. The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. The presence of hCG receptors in the human endometrium suggests that this embryonic signal may exert a local function in this tissue. Our objectives were to investigate the possible association between PG and MCP-1 and to examine the role of hCG in interleukin-1beta (IL-1beta)-regulated PG and MCP-1 production in human endometrium.

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