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Inflammatory mediators such as prostaglandins (PG), chemokines, cytokines and their interactions regulate reproductive functions. The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. The presence of hCG receptors in the human endometrium suggests that this embryonic signal may exert a local function in this tissue. Our objectives were to investigate the possible association between PG and MCP-1 and to examine the role of hCG in interleukin-1beta (IL-1beta)-regulated PG and MCP-1 production in human endometrium.

Independent regulation of prostaglandins and monocyte chemoattractant protein-1 by interleukin-1β and hCG in human endometrial cells