Fetal cell-free DNA circulates in the plasma of pregnant mice: relevance for animal models of fetomaternal trafficking | Zendy

Kiarash Khosrotehrani | Zendy; Tuangsit Wataganara | Zendy; Diana W. Bianchi | Zendy; Kirby L. Johnson | Zendy

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Fetal cell-free DNA circulates in the plasma of pregnant mice: relevance for animal models of fetomaternal trafficking

Author(s) -

Kiarash Khosrotehrani,

Tuangsit Wataganara,

Diana W. Bianchi,

Kirby L. Johnson

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh445

Subject(s) - congenic , fetus , andrology , pregnancy , cell free fetal dna , biology , medicine , microbiology and biotechnology , prenatal diagnosis , gene , genetics

Cell-free fetal DNA (fDNA) can be detected in maternal plasma throughout human pregnancy and is rapidly cleared after delivery. fDNA measurement has clinical application in many complications of pregnancy. Our aim was to determine if fDNA could be detected in maternal plasma during pregnancy in a mouse model system. We then compared the levels of fDNA during pregnancies in which the mother and fetus were either congenic or allogenic.

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