A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations | Zendy

MariePierre Primi | Zendy; A. Senn | Zendy; Markus Montag | Zendy; H. van der Ven | Zendy; Jacqueline Mandelbaum | Zendy; Anna Veiga | Zendy; Pedro N. Barri | Zendy; M. Germond | Zendy

Open Access

A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations

Author(s) -

MariePierre Primi,

A. Senn,

Markus Montag,

H. van der Ven,

Jacqueline Mandelbaum,

Anna Veiga,

Pedro N. Barri,

M. Germond

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh430

Subject(s) - hatching , randomized controlled trial , medicine , prospective cohort study , biology , ecology

Assisted hatching (AH) techniques, designed for facilitating the embryo escape out of the zona pellucida (ZP) have been used in IVF centres since 1992. The initial indications for AH were patient's age, ZP thickness, high basal FSH and repeated IVF failures. Several retrospective and prospective studies assessing AH in these indications have given disparate results. Our aims were to evaluate the benefits of AH and immunosuppressive/antibiotic treatment (IA) in patients with either a poor prognosis of success, previous implantation failures or transfers of cryopreserved embryos.

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