Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis | Zendy

Miyuki Harada | Zendy; Yutaka Osuga | Zendy; Tetsuya Hirata | Zendy; Yasushi Hirota | Zendy; Kaori Koga | Zendy; Osamu Yoshino | Zendy; Chieko Morimoto | Zendy; Toshihiro Fujiwara | Zendy; Mikio Momoeda | Zendy; Tetsu Yano | Zendy; Osamu Tsutsumi | Zendy; Yuji Taketani | Zendy

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Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis

Author(s) -

Miyuki Harada,

Yutaka Osuga,

Tetsuya Hirata,

Yasushi Hirota,

Kaori Koga,

Osamu Yoshino,

Chieko Morimoto,

Toshihiro Fujiwara,

Mikio Momoeda,

Tetsu Yano,

Osamu Tsutsumi,

Yuji Taketani

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh412

Subject(s) - osteoprotegerin , endometriosis , medicine , peritoneal fluid , gynecology , endocrinology , receptor , activator (genetics)

Failure of apoptosis of refluxed endometrial cells within the peritoneal cavity is a possible etiologic factor for development of endometriosis. Osteoprotegerin (OPG) is a survival factor that exerts its effect by binding to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), thus preventing TRAIL from binding to the apoptosis receptors DR4 and DR5. In the present study, we addressed the possibility that the TRAIL/OPG system is involved in the pathogenesis of endometriosis.

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