Association of the T45G polymorphism in exon 2 of the adiponectin gene with polycystic ovary syndrome: role of 4-androstenedione | Zendy

Dimitrios Panidis | Zendy

Open Access

Association of the T45G polymorphism in exon 2 of the adiponectin gene with polycystic ovary syndrome: role of 4-androstenedione

Author(s) -

Dimitrios Panidis

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh336

Subject(s) - polycystic ovary , endocrinology , medicine , insulin resistance , adiponectin , hyperandrogenism , insulin , body mass index , genotype , obesity , free androgen index , biology , androstenedione , androgen , hormone , gene , genetics

Insulin resistance is a prominent feature of polycystic ovary syndrome (PCOS), independent of obesity. It is possible that insulin resistance in PCOS is genetically determined. Adiponectin is a protein that modulates insulin action and is regarded as a possible link between adiposity and insulin resistance. The objective of this study was to examine the role of the adiponectin gene T45G polymorphism, located in exon 2, in PCOS, since this polymorphism has been shown to be associated with obesity and insulin resistance.

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