Carbohydrate analysis of the zona pellucida and cortical granules of human oocytes by means of ultrastructural cytochemistry | Zendy

María JiménezMovilla | Zendy

Open Access

Carbohydrate analysis of the zona pellucida and cortical granules of human oocytes by means of ultrastructural cytochemistry

Author(s) -

María JiménezMovilla

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh311

Subject(s) - zona pellucida , glycoprotein , cytochemistry , glycosylation , cortical granule , biology , ultrastructure , zona pellucida glycoprotein , sperm , carbohydrate , microbiology and biotechnology , biochemistry , oocyte , anatomy , genetics , embryo

The zona pellucida (ZP), the mammalian oocyte coat, consists of a restricted number of highly glycosylated proteins. In vitro sperm binding studies suggest a higher binding affinity for the outer region of the ZP compared to its inner region in different species. However, the reason for this difference in binding distribution remains unresolved. Many studies suggest that the carbohydrate sequences linked to ZP glycoproteins act as ligands for sperm binding to this matrix.

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