Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads | Zendy

Ewa RajpertDe Meyts | Zendy

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Developmental expression of POU5F1 (OCT-3/4) in normal and dysgenetic human gonads

Author(s) -

Ewa RajpertDe Meyts

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh265

Subject(s) - gonocyte , biology , gonadoblastoma , gonad , development of the gonads , endocrinology , ovary , stem cell , medicine , folliculogenesis , homeobox protein nanog , embryonic stem cell , andrology , embryogenesis , embryo , induced pluripotent stem cell , microbiology and biotechnology , spermatogenesis , karyotype , genetics , sertoli cell , gene , chromosome

To investigate how long fetal germ cells retain pluripotency, which may be linked to their ability to transform into histologically variable tumours, we examined the expression of OCT-3/4 (POU5F1), a transcription factor essential for the maintenance of totipotency in embryonic stem cells.

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