An in vitro model for purging of tumour cells from ovarian tissue | Zendy

Carolien P. Schröder | Zendy; Hetty TimmerBosscha | Zendy; JG Wijchman | Zendy; de Louis Leij | Zendy; H. Hollema | Zendy; MJ Heineman | Zendy; Elisabeth G.E. de Vries | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

An in vitro model for purging of tumour cells from ovarian tissue

Author(s) -

Carolien P. Schröder,

Hetty TimmerBosscha,

JG Wijchman,

de Louis Leij,

H. Hollema,

MJ Heineman,

Elisabeth G.E. de Vries

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh244

Subject(s) - ovarian cancer , biology , cell , cell culture , cytotoxic t cell , cell growth , programmed cell death , in vitro , cancer research , andrology , microbiology and biotechnology , cancer , apoptosis , medicine , biochemistry , genetics

Cryopreservation and autografting of ovarian tissue may preserve fertility after cancer treatment, but could be hampered by tumour cell contamination. Epithelial tumour cell lysis can be obtained with cytotoxic T cell retargeting through the bispecific antibody BIS-1, with combined affinity for the T-cell receptor and epithelial glycoprotein-2 (EGP-2). Our aim was to study the concept of tumour cell purging in the setting of a suspension of ovarian tissue.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research