Sperm FISH studies in seven male carriers of Robertsonian translocation t(13;14)(q10;q10) | Zendy

Ester Antón | Zendy; Joan Blanco | Zendy; J. Egozcue | Zendy; Francesca Vidal | Zendy

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Sperm FISH studies in seven male carriers of Robertsonian translocation t(13;14)(q10;q10)

Author(s) -

Ester Antón,

Joan Blanco,

J. Egozcue,

Francesca Vidal

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh232

Subject(s) - robertsonian translocation , synapsis , biology , meiosis , chromosomal translocation , genetics , chromosome , fluorescence in situ hybridization , sperm , fish <actinopterygii> , karyotype , gene , fishery

Robertsonian translocation t(13;14) is one of the most common structural reorganization in humans, but meiotic segregation studies in these carriers are still limited. The segregation pattern of the chromosomes involved, the possible influence of the translocated chromosomes on the synapsis and disjunction of other chromosome pairs [interchromosomal effects (ICE)] and the rates of unbalanced spermatozoa produced still deserve attention, not only to obtain a better characterization of the meiotic behaviour of this reorganization, but also to offer carrier couples accurate genetic counselling.

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