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Chromosome number and development of artificial mouse oocytes and zygotes
Author(s) -
Björn Heindryckx
Publication year - 2004
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deh217
Subject(s) - zygote , biology , somatic cell , oocyte activation , andrology , human fertilization , embryo , oocyte , ploidy , chromosome , fertilisation , genetics , reproductive technology , embryogenesis , medicine , gene
Infertility due to the absence of gametes is one of the last frontiers in reproductive medicine. Sperm or oocyte donation is currently the only treatment option but this approach lacks the genetic contribution of both partners. Artificial production of gametes through haploidization may offer an alternative strategy. The aim of this study was to evaluate the efficiency of producing artificial oocytes and zygotes with correct chromosome number.

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