Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells | Zendy

Takeshi Yamada | Zendy

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Progesterone down-regulates insulin-like growth factor-I expression in cultured human uterine leiomyoma cells

Author(s) -

Takeshi Yamada

Publication year - 2004

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh146

Subject(s) - uterine leiomyoma , leiomyoma , endocrinology , medicine , progesterone receptor , insulin like growth factor , biology , radioimmunoassay , growth factor , receptor , fetal bovine serum , estrogen receptor , estrogen , cell culture , uterus , cancer , pathology , genetics , breast cancer

Insulin-like growth factor-I (IGF-I) plays crucial roles in uterine leiomyoma cell growth through stimulating proliferation and inhibiting apoptosis. The present study was conducted to elucidate whether progesterone affects IGF-I and its receptor expression in cultured leiomyoma cells.

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