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Caspase-dependent and -independent DNA fragmentation in Sertoli and germ cells from men with primary testicular failure: relationship with histological diagnosis
Author(s) -
Jan Tesařík
Publication year - 2004
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deh081
Subject(s) - sertoli cell , dna fragmentation , apoptosis , germ cell , phosphatidylserine , biology , caspase 3 , microbiology and biotechnology , fragmentation (computing) , spermatogenesis , andrology , medicine , endocrinology , programmed cell death , genetics , phospholipid , ecology , membrane , gene
Germ cell elimination and sperm DNA fragmentation in men with primary testiculopathies involve apoptosis-related processes whose mechanisms are poorly understood. This study examines the participation of typical (caspase-dependent) and atypical (caspase-independent) pathways in these processes.

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