Caspase-dependent and -independent DNA fragmentation in Sertoli and germ cells from men with primary testicular failure: relationship with histological diagnosis
Author(s) -
Jan Tesařík
Publication year - 2004
Publication title -
human reproduction
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.446
H-Index - 226
eISSN - 1460-2350
pISSN - 0268-1161
DOI - 10.1093/humrep/deh081
Subject(s) - sertoli cell , dna fragmentation , apoptosis , germ cell , phosphatidylserine , biology , caspase 3 , microbiology and biotechnology , fragmentation (computing) , spermatogenesis , andrology , medicine , endocrinology , programmed cell death , genetics , phospholipid , ecology , membrane , gene
Germ cell elimination and sperm DNA fragmentation in men with primary testiculopathies involve apoptosis-related processes whose mechanisms are poorly understood. This study examines the participation of typical (caspase-dependent) and atypical (caspase-independent) pathways in these processes.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom