The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial | Zendy

Seyide Soysal | Zendy; Mehmet Emin Soysal | Zendy; Suzan Özer | Zendy; Nýhat Gul | Zendy; Tuğba Gezgin | Zendy

Open Access

The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial

Author(s) -

Seyide Soysal,

Mehmet Emin Soysal,

Suzan Özer,

Nýhat Gul,

Tuğba Gezgin

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh035

Subject(s) - goserelin , medicine , anastrozole , endometriosis , urology , aromatase inhibitor , randomized controlled trial , surgery , aromatase , breast cancer , cancer

Among patients using GnRH analogues for endometriosis it has been postulated that peripheral and inflammation-induced in-situ aromatization of adrenal androgens are probably the main reasons for the high rates of failure during follow-up. We hypothesized that in cases with premenopausal severe endometriosis, use of a combination of anastrozole and goserelin to achieve almost maximal endocrine blockade of estrogen synthesis after conservative surgery may increase the pain-free interval and reduce the recurrence rates as compared to goserelin alone.

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