Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles | Zendy

L. M. Mitchell | Zendy

Open Access

Expression of nitric oxide synthase and effect of substrate manipulation of the nitric oxide pathway in mouse ovarian follicles

Author(s) -

L. M. Mitchell

Publication year - 2003

Publication title -

human reproduction

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.446

H-Index - 226

eISSN - 1460-2350

pISSN - 0268-1161

DOI - 10.1093/humrep/deh032

Subject(s) - theca , nitric oxide , nitric oxide synthase , medicine , citrulline , endocrinology , oocyte , follicle , ovarian follicle , arginine , ovulation , biology , ovary , folliculogenesis , enos , in situ hybridization , andrology , chemistry , microbiology and biotechnology , biochemistry , messenger rna , embryo , embryogenesis , amino acid , hormone , gene

Nitric oxide (NO) is a cell messenger with multiple actions in different biological systems, implicated in the control of follicle and oocyte function. NO is formed from L-arginine by isoforms of nitric oxide synthase (NOS) via NG-hydroxy-L-arginine, with L-citrulline as a byproduct. This study aimed to show how modulation of NO by manipulating NOS substrates would affect mouse follicle growth and ovulation in vitro, where vascular effects of NO are attenuated.

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